The spatiotemporal ecology of Oropouche virus across Latin America: a multidisciplinary, laboratory-based, modelling study
Hot from the press!
Fischer et al. 2025. The spatiotemporal ecology of Oropouche virus across Latin America: a multidisciplinary, laboratory-based, modelling study. The Lancet Infectious Diseases DOI: 10.1016/S1473-
The paper was presented at hashtagESCMID 2025 by Jan Felix Drexler who led this huge collaborative effort.
Carlo Fischer, Anna Frühauf, Lucia Inchauste and colleagues demonstrated that OROV infections seem widely under-reported in Latin America. Oropouche seropositivity is much higher than previously thought, up 30% in some populations. The authors did not find evidence of immune escape or major antigenic differences in the isolate of the virus causing the current outbreak. Reasons for increased recent spread of OROV are multifactorial, although climatic variables contributed 60% to the variability in the models and appeared to be key factors favouring the spread of OROV.
This new study (the largest study to analyse serum samples for OROV) emphasises the need for the development of an OROV vaccine (does not exist at present), better education and awareness of healthcare workers in the Americas regarding signs/symptoms of OROV, increased diagnostic strategies, and surveillance strategies to mitigate future outbreaks which are likely to become more widespread due to climate change.
Read the full paper here: https://lnkd.in/d3KSBVSu
Read the comment by Daniel Romero-Alvareza and Carrie A Manore here: https://lnkd.in/dPas6Ry4
Hear the podcast episode for this study with Fernando Bozza and Jan Felix Drexler here:
Buzzsprout-https://lnkd.in/
Spotify– https://lnkd.in/dyjxqww8
Apple– https://lnkd.in/dAG3ham2
This new study (the largest study to analyse serum samples for OROV) emphasises the need for the development of an OROV vaccine (does not exist at present), better education and awareness of healthcare workers in the Americas regarding signs/symptoms of OROV, increased diagnostic strategies, and surveillance strategies to mitigate future outbreaks which are likely to become more widespread due to climate change.
Read the full paper here: https://lnkd.in/d3KSBVSu
Read the comment by Daniel Romero-Alvareza and Carrie A Manore here: https://lnkd.in/dPas6Ry4
Hear the podcast episode for this study with Fernando Bozza and Jan Felix Drexler here:
Buzzsprout-https://lnkd.in/
Spotify– https://lnkd.in/dyjxqww8
Apple– https://lnkd.in/dAG3ham2
